Generic name: hydrocortisone cypionate
Dosage form: Oral Suspension
Drug class:Glucocorticoids
Medically reviewed by Drugs.com. Last updated on Jun 21, 2021.
On This Page
Cortef Oral Suspension Description
Cortef Oral Suspension contains hydrocortisone cypionate which is a glucocorticoid. Glucocorticoids are adrenocortical steroids, both naturally occurring and synthetic, which are readily absorbed from the gastrointestinal tract. Hydrocortisone cypionate is the water-insoluble cypionate ester of hydrocortisone. It is both tasteless and odorless, and by the oral route and in equimolar doses, is equivalent to hydrocortisone free alcohol in biologic activity (rat liver-glycogen assay). Determinations of plasma and urinary 17-hydroxycorticoid levels in man following oral administration indicate that this ester is as efficiently absorbed and metabolized as the free alcohol.
The chemical name for hydrocortisone cypionate is pregn-4-ene-3,20-dione,21-(3-cyclopentyl-1-oxopropoxy)-11,17-dihydroxy-,(11β)- and the molecular weight is 486.65. The structural formula is represented below:
CORTEF, a preparation for oral use, contains 13.4 mg hydrocortisone cypionate (equivalent to 10 mg hydrocortisone) in each 5 mL. CORTEF also contains the following inactive ingredients: benzoic acid, citric acid, FD&C yellow ...
