Generic name:burosumab [ bur-OH-sue-mab ]
Drug class:Miscellaneous metabolic agents
What is Crysvita?
Crysvita is a monoclonal antibody that targets and blocks the activity of a blood protein called FGF23. In a genetic condition called X-linked hypophosphatemia (HYE-poe-fos-fa-TEEM-ee-a), low phosphate levels in blood are caused by abnormally high levels of FGF23 protein, which causes the kidneys to stop reabsorbing phosphate into the bloodstream.
Blocking the FGF23 protein allows the kidneys to restore and maintain normal phosphate levels. Phosphate is important for the strength of your bones and teeth. Low phosphate levels can lead to bone deformities and growth problems.
Crysvita is used to normalize phosphate levels in adults and children who are at least 1 year old and have X-linked hypophosphatemia.
Crysvita may also be used for purposes not listed in this medication guide.
Warnings
You should not use Crysvita if you have severe kidney disease, or if you currently take phosphate or vitamin D by mouth.
Before taking this medicine
You should not use Crysvita if you are allergic to it, or if you have:
severe or end-stage kidney disease; or
if you currently take phosphate or vitamin D by mouth.
Tell your doctor if you have ever had:
kidney disease; or
restless leg syndrome.
It is not known whether Crysvita will harm an unborn baby. Tell your doctor if you are pregnant or if you become pregnant while using Crysvita.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any...
