Dabrafenib
Generic name: dabrafenib [ da-bRAF-e-nib ]
Brand name: Tafinlar
Dosage form: oral capsule (50 mg; 75 mg)
Drug class:Multikinase inhibitors
What is dabrafenib?
Dabrafenib is used alone or in combination with another medicine called trametinib (Mekinist) to treat certain types of cancer in people who have a "BRAF" gene mutation. dabrafenib is for use in treating:
melanoma (skin cancer) that cannot be treated with surgery or has spread to other parts of the body, or to prevent melanoma from coming back after surgery;
non-small cell lung cancer that has spread to other parts of the body; or
advanced or metastatic thyroid cancer that has spread and for which there are no other treatment options.
Dabrafenib may also be used for purposes not listed in this medication guide.
Warnings
Using dabrafenib with trametinib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms.
Before taking this medicine
You should not use dabrafenib if you are allergic to it.
Tell your doctor if you have ever had:
heart disease;
bleeding problems;
liver or kidney disease;
diabetes (dabrafenib may raise your blood sugar);
eye problems (especially a problem with your retina); or
a genetic enzyme deficiency called glucose-6-phosphate dehydrogenase (G6PD) deficiency.
Using dabrafenib with trametinib may increase your risk of developing a certain type of skin cancer. Ask your doctor about your specific risk. Tell your doctor if you notice any new skin symptoms such as redness, warts, sores that will not heal, or a mole that has changed in size or color.
You may need to have a negative pregnancy test before starting this treatment.
Both men and women using dabrafenib should use effective birth control to prevent pregnancy. Dabrafenib can harm an unborn baby or cause birth defects if the mother or father is using this medicine.
Keep using birth control for at least 2 weeks after your last dose. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using dabrafenib.
If you use dabrafenib and trametinib together: Keep using birth control for at least 4 months after your last dose of these two medicines.
Dabrafenib can make hormonal birth control less effective, including birth control pills, injections, impl...
