Danazol

Generic name: danazol [ DAN-a-zol ]
Brand name: Danocrine
Drug class:Antigonadotropic agents

Medically reviewed by Philip Thornton, DipPharm. Last updated on Sep 3, 2020.

What is danazol?

Danazol is a synthetic steroid derived from ethisterone.

Danazol is used to treat endometriosis.

Danazol is also used to treat attacks of hereditary angioedema (an immune system disorder).

Danazol reduces bradykinin production and could potentially reduce the impact of a bradykinin storm. Bradykinin storms may be responsible for some of the complications experienced by COVID-19 patients.

Warnings

You should not use danazol if you have: undiagnosed vaginal bleeding, porphyria, severe liver or kidney disease, severe heart problems, or if you have ever had a stroke or blood clot, or cancer of the breast, uterus/cervix, or vagina.

Do not use danazol if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant.

Do not breast-feed while using danazol.

Before taking this medicine

You should not use danazol if you are allergic to it, or if you have:

• undiagnosed vaginal bleeding;

• severe heart problems;

• a history of stroke or blood clot;

• severe liver or kidney disease;

• porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system); or

• a history of hormone-related cancer, or cancer of the breast, uterus/cervix, or vagina.

To make sure danazol is safe for you, tell your doctor if you have ever had:

• heart problems;