Dapiprazole Ophthalmic Solution

Generic name: dapiprazole hydrochloride
Dosage form: ophthalmic solution
Drug class:Miscellaneous ophthalmic agents

Medically reviewed by Drugs.com. Last updated on Jan 1, 2022.

DESCRIPTION:

For ophthalmic use only.

Dapiprazole hydrochloride is an alpha-adrenergic blocking agent.

Dapiprazole hydrochloride is 5,6,7,8-tetrahydro-3-[2-(4- o .tolyl-1-piperazinyl)ethyl]- s -triazolo[4,3-a]pyridine hydrochloride.

Dapiprazole hydrochloride has the empirical formula C 19H 27N 5 • HCl and a molecular weight of 361.93.

The structural formula for dapiprazole hydrochloride is:

Dapiprazole hydrochloride is a sterile, white, lyophilized powder soluble in water.

Dapiprazole hydrochloride ophthalmic solution, 0.5% is a clear, colorless, slightly viscous solution for topical application. Each mL (when reconstituted as directed) contains 5 mg of dapiprazole hydrochloride as the active ingredient.

The reconstituted solution has a pH of approximately 6.6 and an osmolarity of approximately 415 mOsm.

The inactive ingredients include: mannitol (2%), sodium chloride, hydroxypropyl methylcellulose (0.4%), edetate sodium (0.01%), sodium phosphate dibasic, sodium phosphate monobasic, water for injection, and benzalkonium chloride (0.01%) as a preservative.

Dapiprazole hydrochloride ophthalmic solution, 0.5% is supplied in a kit consisting of one vial of dapiprazole hydrochloride (25 mg), one vial of diluent (5 mL) and one dropper for dispensing.

CLINICAL PHARMACOLOGY:

Dapiprazole hydrochloride ophthalmic solution acts through blocking the alpha-adrenergic receptors in smooth muscle. Dapiprazole hydrochloride ophthalmic solution produces miosis through an effect on the dilator muscle of the iris.

Dapiprazole hydrochloride ophthalmic solution does not have any significant activity on ciliary muscle contraction and, therefore does not induce a significant change in the anterior chamber depth or the thickness of the lens.

Dapiprazole hydrochloride ophthalmic solution has demonstrated safe and rapid reversal of mydriasis produced by phenylephrine and to a lesser degree tropicamide. In patients with decreased accommodative amplitude due to treatment with tropicamide, dapiprazole hydrochloride ophthalmic solution partially restores the accommodative amp...