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Depo-subQ Provera 104
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Depo-subQ Provera 104

Generic name:medroxyprogesterone (injection) [ me-DROX-ee-proe-JES-ter-one ]
Dosage form: subcutaneous suspension (104 mg/0.65 mL)
Drug classes:Contraceptives, Hormones / antineoplastics, Progestins

Medically reviewed by Philip Thornton, DipPharm. Last updated on May 9, 2022.

What is Depo-subQ Provera 104?

Depo-subQ Provera 104 (medroxyprogesterone) is a form of progesterone, a female hormone that prevents ovulation (the release of an egg from an ovary). Medroxyprogesterone also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.

Depo-subQ Provera 104 is used as contraception (birth control) to prevent pregnancy.

Depo-subQ Provera 104 is also used to reduce pain caused by endometriosis. Symptoms of endometriosis arise when cells normally inside your uterus grow outside the uterus. The cells respond to menstrual cycle hormones, and may cause painful periods, pelvic pain, and painful sex.

Depo-subQ provera 104 is given as a subcutaneous injection (shot given under the skin) every 3 months.

Warnings

You should not use Depo-subQ Provera 104 if you have: undiagnosed vaginal bleeding, liver disease, breast cancer, if you are pregnant, or if you have ever had a stroke or blood clot.

Depo-subQ Provera 104 can decrease the calcium stored in your bones, which may cause bone loss (osteoporosis) when the medicine is used over long periods of time. Bone loss may not be reversible.

You may be more likely to have a broken bone if your bones get weak from calcium loss, especially after menopause. You should not use Depo-subQ Provera 104 for longer than 2 years unless other birth control methods are not right for you.

Before taking this medicine

You may need to have a negative pregnancy test before you start Depo-subQ Provera 104.

You should not use Depo-subQ Provera 104 if you are pregnant, or if you have:

  • abnormal vaginal bleeding that has not been checked by a doctor;

  • liver disease;

  • breast cancer; or

  • a history of stroke or blood clot.

Depo-subQ Provera 104 can decrease the calcium stored in your bones, which may cause bone loss (osteoporosis) when the medicine is used over long periods of time. Bone loss may not be reversible.

You may be more likely to have a broken bone if your bones get weak from calcium loss, especi...