D.H.E. 45 (injection)
Generic name:dihydroergotamine (injection) [ dye-HYE-droe-er-GOT-a-meen ]
Drug class:Antimigraine agents
What is D.H.E. 45?
D.H.E. 45 is an ergot alkaloid medicine that is used to treat a migraine or cluster headache attack. D.H.E. 45 will not prevent headaches or reduce the number of attacks.
This medicine is not for common tension headaches or daily use.
D.H.E. 45 may also be used for purposes not listed in this medication guide.
Warnings
Tell your doctor about all your other medicines. Some drugs should not be used with D.H.E. 45.
Before taking this medicine
You should not use D.H.E. 45 if you are allergic to it, or if you have:
heart disease, chest pain (angina), coronary artery disease, a history of a heart attack or stroke;
circulation problems such as peripheral vascular disease;
uncontrolled high blood pressure;
sepsis (a severe reaction to an infection).
severe liver or kidney disease;
if you are allergic to D.H.E. 45 or other ergot medicine (ergonovine, ergotamine, methylergonovine); or
if you have recently had heart or blood vessel surgery (such as bypass surgery).
D.H.E. 45 can affect blood circulation to your uterus. Do not use if you are pregnant. Ask your doctor for a safer medicine to use during pregnancy, since having migraine headaches may cause complications in the mother and the baby.
Do not breastfeed.
Some drugs should not be used with D.H.E. 45. Your treatment plan may change if you also use:
an antibiotic such as clarithromycin or erythromycin;
antifungal medicine such as itraconazole or ketoconazole; or
antiviral medicine for HIV or hepatitis C.
Tell your doctor if you have ever had:
blood circulation problems in your arms, hands, legs, or feet;
chest pain, shortness of breath;
liver or kidney disease;
