Dianeal PD-1

Generic name: Sodium chloride, sodium lactate, calcium chloride, magnesium chloride and dextrose
Dosage form: injection, solution
Drug class:Intravenous nutritional products

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Dianeal PD-1 Description

Dianeal PD-1 peritoneal dialysis solutions in AMBU-FLEX III containers with a flanged port are sterile, nonpyrogenic solutions for intraperitoneal administration only. They contain no bacteriostatic or antimicrobial agents or added buffers.

Composition, calculated osmolarity, pH and ionic concentrations are shown in Table 1.

Potassium is omitted from DIANEAL solutions because dialysis may be performed to correct hyperkalemia. In situations in which there is a normal serum potassium level or hypokalemia, the addition of potassium chloride (up to a concentration of 4 mEq/L) may be indicated to prevent severe hypokalemia. Addition of potassium chloride should be made after careful evaluation of serum and total body potassium and only under the direction of a physician. Frequent monitoring of serum electrolytes is indicated.

The osmolarities shown in Table 1 are calculated values. As an example, measured osmolarity by freezing point depression determination of Dianeal PD-1 peritoneal dialysis solution with 1.5% dextrose is approximately 334 mOsmol/L, compared with measured values in normal human serum of 280 mOsmol/L.

The plastic container is fabricated from a specially formulated polyvinyl chloride (PL 146 Plastic). The amount of water that can permeate from inside the container into the overwrap is insufficient to affect the solution significantly.

Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, e.g., di-2-ethylhexyl phthalate (DEHP), up to 5 parts per million; however, the safety of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies.

Dianeal PD-1 - Clinical Pharmacology

Peritoneal dialysis is a procedure for removing toxic subst...