Class: Other Nonsteroidal Anti-inflammatory Agents
Chemical Name: 2-[(2,6-dichlorophenyl)amino] benzeneacetic acid, monopotassium salt
Molecular Formula: C14H11C12NO2•KC14H11C12NO2.NaC20H24Cl2N2O3
CAS Number: 15307-81-0
Brands: Cambia, Flector, Licart, Pennsaid, Voltaren, Zipsor
Warning
- Cardiovascular Risk
Increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke). Risk may occur early in treatment and may increase with duration of use. (See Cardiovascular Thrombotic Effects under Cautions.)
Contraindicated in the setting of CABG surgery.
- GI Risk
Increased risk of serious (sometimes fatal) GI events (e.g., bleeding, ulceration, perforation of the stomach or intestine). Serious GI events can occur at any time and may not be preceded by warning signs and symptoms. Geriatric individuals and patients with history of peptic ulcer disease and/or GI bleeding are at greater risk for serious GI events. (See GI Effects under Cautions.)
Introduction
Prototypical NSAIA; phenylacetic acid derivative; structurally related to meclofenamate sodium and mefenamic acid.
Uses for Diclofenac (Systemic)
Inflammatory Diseases
Orally for symptomatic treatment of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Orally in fixed combination with misoprostol for the symptomatic treatment of osteoarthritis and rheumatoid arthritis in patients at high risk for developing NSAIA-induced gastric or duodenal ulcers and in patients at high risk for developing complications from these ulcers.
Topically (as 1% gel or 1.5 or 2% solution) for the...
