Diupres
Generic name: reserpine and chlorothiazide
Dosage form: Tablets
Drug class:Antiadrenergic agents (peripheral) with thiazides
Medically reviewed by Drugs.com. Last updated on Feb 21, 2022.
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This fixed combination drug is not indicated for initial therapy of hypertension. Hypertension requires therapy titrated to the individual patient. If the fixed combination represents the dosage so determined, its use may be more convenient in patient management. The treatment of hypertension is not static, but must be re-evaluated as conditions in each patient warrant.
Diupres Description
Diupres1 combines two antihypertensives: DIURIL1 (Chlorothiazide) and reserpine.
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Chlorothiazide
Chlorothiazide is a diuretic and antihypertensive. Its chemical name is 6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is C7H6ClN3O4S2 and its structural formula is:
Chlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 295.73, which is very slightly soluble in water, but readily soluble in dilute aqueous sodium hydroxide. It is soluble in urine to the extent of about 150 mg per 100 mL at pH 7.
Reserpine
The chemical name of reserpine is 11, 17α-dimethoxy-18β-[(3,4,5-trimethoxybenzoyl)oxy]-3β, 20α-yohimban-16β-carboxylic acid methyl ester. It is a crystalline alkaloid derived from Rauwolfia serpentina. Its empirical formula is C33H40N2O9 and its structural formula is:
Reserpine is a white or pale bu...
