Divigel

Generic name:estradiol topical (for use on skin) [ ess-tra-DYE-ol-TOP-ik-al ]
Drug class:Estrogens

Medically reviewed by Philip Thornton, DipPharm. Last updated on Jun 14, 2021.

What is Divigel?

Divigel is a clear, colorless gel, which is odorless when dry. Estradiol is a form of estrogen, a female sex hormone that regulates many processes in the body.

Divigel is used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.

Divigel may also be used for purposes not listed in this medication guide.

Warnings

Do not use Divigel if you are pregnant.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Report any unusual vaginal bleeding right away.

Using Divigel can increase your risk of blood clots, stroke, heart attack, or cancer of the breast, uterus, or ovaries. Estradiol should not be used to prevent heart disease, stroke, or dementia.

Estradiol topical is absorbed through the skin and can cause side effects in a child who comes into contact with the skin where you have applied Divigel.

Before using this medicine

You should not use Divigel if you have:

• abnormal vaginal bleeding that has not been checked by a doctor;

• any type of breast, uterine, or hormone-dependent cancer;

• a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);

• liver disease;

• a bleeding or blood-clotting disorder;

• if you are pregnant or may become pregnant; or

• if you have ever had an allergic reaction to estradiol topical.

Estradiol will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Estradiol may also increase your risk of uterine or ovarian cancer. Talk with your doctor about your individual risks.

To make sure Divigel is safe for you, tell your doctor if you have:

• unusual vaginal bleeding;

• heart disease;

• asthma;

• epilepsy or other seizure disorder;

• liver or kidney disease;

• hereditary angioedema;

• endometriosis;

• a thyroid disorder;

• lupus;

• high levels of calcium in your blood (hypercalcemia);

• migraines;

• gallbladder disease; or

• risk factors for coronary artery disease (such as diabetes, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40, or if you have had a hysterectomy).

Do not use Divigel if you are pregnant. U...