Generic name: dobutamine hydrochloride
Dosage form: injection, solution
Drug classes:Cardiac stressing agents, Catecholamines, Inotropic agents, Vasopressors
Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.
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Dobutamine Injection Description
Dobutamine Injection, USP is 1,2-benzenediol, 4-[2-[[3-(4-hydro-xphenyl)-1-methylpropyl]amino]ethyl]-hydrochloride, (±). It is a synthetic catecholamine.
The clinical formulation is supplied in a sterile form for intravenous use only. Each mL contains: Dobutamine hydrochloride, equivalent to 12.5 mg (41.5 umol) dobutamine; 0.24 mg sodium metabisulfite (added during manufacture), and water for injection, pH adjusted between 2.5 to 5.5 with hydrochloric acid and/or sodium hydroxide. Dobutamine is oxygen sensitive.
Dobutamine Injection - Clinical Pharmacology
Dobutamine is a direct-acting inotropic agent whose primary activity results from stimulation of the β receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. It does not ccause the release of endogenous norepinephrine, as does dopamine. In an...
