Dolasetron

Medically reviewed by Drugs.com. Last updated on Apr 25, 2022.

Commonly used brand name(s)

In the U.S.

• Anzemet

Available Dosage Forms:

• Solution

Therapeutic Class: Antiemetic

Pharmacologic Class: Dolasetron

Uses for dolasetron

Dolasetron injection is used to prevent and treat nausea and vomiting that may happen after surgery.

Dolasetron is available only with your doctor's prescription.

Before using dolasetron

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dolasetron, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to dolasetron or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of dolasetron injection to prevent and treat nausea and vomiting that occurred after surgery in children 2 years of age and older. However, safety and efficacy have not been established in children younger than 2 years of age.

Use of dolasetron injection to prevent nausea and vomiting caused by cancer medicines in children is not recommended.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dolasetron injection in the elderly. However, elderly patients are more likely to have heart rhythm problems (eg, prolonged QT, PR, and QRS interval), which may require caution and an adjustment in the dose for patients receiving dolasetron injection.

Use of dolasetron injection to prevent nausea and vomiting caused by cancer medicines in geriatric patients is not recommended.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving dolasetron, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using dolasetron with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Apomorphine
• Bepridil
• Cisapride
• Dronedarone
• Levoketoconazole
• Levomethadyl
• Mesoridazine
• Pimozide
• Piperaquine
• Saquinavir
• Sparfloxacin
• Terfenadine
• Thioridazine
• Ziprasidone

Using dolasetron with any of the following medicines is usually not recommend...