Dupilumab (Subcutaneous)

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Commonly used brand name(s)

In the U.S.

• Dupixent

Available Dosage Forms:

• Solution

Therapeutic Class: Dermatological Agent

Pharmacologic Class: Monoclonal Antibody

Uses for dupilumab

Dupilumab injection is used alone or in combination with other medicines (eg, topical corticosteroids) to treat moderate to severe atopic dermatitis in patients who have been treated with topical medicines that did not work well or who cannot use topical treatment.

Dupilumab injection is also used together with other medicines to treat moderate to severe asthma in patients whose asthma is hard to control or who are dependent on steroid medicines. Dupilumab helps prevent severe asthma attacks (exacerbations) and can improve your breathing. Dupilumab will not relieve an asthma attack that has already started.

Dupilumab injection is also used as additional treatment for poorly controlled chronic rhinosinusitis with nasal polyposis (CRSwNP).

Dupilumab is available only with your doctor's prescription.

Before using dupilumab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dupilumab, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to dupilumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of dupilumab injection to treat asthma or atopic dermatitis in children younger than 6 years of age or to treat chronic rhinosinusitis with nasal polyposis in children. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dupilumab injection in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking dupilumab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using dupilumab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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