Emapalumab-lzsg (Intravenous)

Medically reviewed by Drugs.com. Last updated on Apr 6, 2022.

Commonly used brand name(s)

In the U.S.

• Gamifant

Available Dosage Forms:

• Solution

Therapeutic Class: Immunological Agent

Pharmacologic Class: Emapalumab

Uses for emapalumab-lzsg

Emapalumab-lzsg injection is used to treat a blood disorder called primary hemophagocytic lymphohistiocytosis (HLH) that is hard to treat (refractory), recurrent, or has worsened (progressive), or when other treatments that have been used did not work well.

Emapalumab-lzsg is to be given only by or under the direct supervision of your doctor.

Before using emapalumab-lzsg

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For emapalumab-lzsg, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to emapalumab-lzsg or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of emapalumab-lzsg injection in newborns and children. Safety and efficacy have been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of emapalumab-lzsg injection in the elderly.

Breastfeeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving emapalumab-lzsg, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using emapalumab-lzsg with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Adenovirus Vaccine
• Bacillus of Calmette and Guerin Vaccine, Live
• Cholera Vaccine, Live
• Dengue Tetravalent Vaccine, Live
• Influenza Virus Vaccine, Live
• Measles Virus Vaccine, Live
• Mumps Virus Vaccine, Live
• Poliovirus Vaccine, Live
• Rotavirus Vaccine, Live
• Rubella Virus Vaccine, Live
• Smallpox Vaccine
• Typhoid Vaccine, Live
• Varicella Virus Vaccine, Live
• Yellow Fever Vaccine
• Zoster Vaccine, Live

Interactions with food/tobacco/alcohol

Certain medicines should not be used at or around the time of eating food or eating certain typ...