Emtricitabine, rilpivirine, and tenofovir

Generic name: emtricitabine, rilpivirine, and tenofovir [ em-trye-SYE-ta-been, RIL-pi-VIR-een, and-ten-OF-oh-vir ]
Brand names: Complera, Odefsey
Dosage form: oral tablet (200 mg-25 mg-25 mg; 200 mg-25 mg-300 mg)
Drug class:Antiviral combinations

Medically reviewed by Drugs.com on Feb 26, 2021. Written by Cerner Multum.

What is emtricitabine, rilpivirine, and tenofovir (Complera or Odefsey)?

Emtricitabine, rilpivirine, and tenofovir is a combination antiviral medicine that is used to treat human immunodeficiency virus (HIV), the virus that can cause acquired immunodeficiency syndrome (AIDS). emtricitabine, rilpivirine, and tenofovir is not a cure for HIV or AIDS.

Emtricitabine, rilpivirine, and tenofovir is for use in adults and children who are at least 12 years old and who weigh at least 77 pounds (35 kilograms).

Emtricitabine, rilpivirine, and tenofovir may also be used for purposes not listed in this medication guide.

Warnings

Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.

If you've ever had hepatitis B, it may become active or get worse after you stop using this medicine. You may need frequent liver function tests for several months.

Before taking this medicine

You should not take Complera or Odefsey if you are allergic to emtricitabine, rilpivirine, or tenofovir.

This medicine is not approved for use by anyone younger than 12 years old or weighing less than 77 pounds (35 kilograms).

There are many other drugs that can make Complera or Odefsey less effective and should not be used at the same time:

• dexamethasone (more than 1 dose);

• St. John's wort;

• tuberculosis medication--rifampin, rifapentine;

• seizure medicine--carbamazepine, oxcarbazepine, phenobarbital, phenytoin; or

• stomach acid reducers--dexlansoprazole, esomeprazole, lansoprazole, om...