Alclometasone

Generic name: Alclometasone dipropionate
Dosage form: cream
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on Apr 1, 2021.

Prescribing Information

For Dermatologic Use Only -
Not for Ophthalmic Use.

Rx only

Alclometasone Description

Alclometasone Dipropionate Cream USP, 0.05% and Alclometasone Dipropionate Ointment USP, 0.05% contain Alclometasone dipropionate, USP (7α-chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate), a synthetic corticosteroid for topical dermatologic use. The corticosteroids constitute a class of primarily synthetic steroids used topically as anti-inflammatory and antipruritic agents. Chemically, Alclometasone dipropionate, USP is C28H37ClO7. It has the following structural formula:

Alclometasone dipropionate, USP has the molecular weight of 521.04 g/mol. It is a white to almost white crystalline powder, sparingly soluble in alcohol, acetone, ethyl acetate and acetonitrile.

Each gram of Alclometasone Dipropionate Cream USP contains 0.5 mg of Alclometasone dipropionate, USP in a hydrophilic, emollient cream base of propylene glycol, white petrolatum, cetearyl alcohol, mono and di-glycerides, PEG 100 stearate, ceteth-20, monobasic sodium phosphate, chlorocresol, phosphoric acid, and purified water.

Each gram of Alclometasone Dipropionate Ointment USP contains 0.5 mg of Alclometasone dipropionate, USP in an ointment base of hexylene glycol, white wax, propylene glycol monopalmitostearate, and white petrolatum.

Alclometasone - Clinical Pharmacology

Like other topical corticosteroids, Alclometasone dipropionate has anti-inflammatory, antipruritic, and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostagl...