Erythra-Derm

Generic name:erythromycin
Dosage form: topical solution
Drug classes:Topical acne agents, Topical antibiotics

Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.

DESCRIPTION:

Erythromycin is an antibiotic produced from a strain of Streptomyces erythraeus. It is basic and readily forms salts with acids.

Chemically, erythromycin is (3R*, 4S*, 5S*, 6R*, 7R*, 9R*, 11R*, 12R*, 13S*, 14R*)-4-[(2,6-Dideoxy-3-C-methyl-3-0-methyl-α-L-ribo-hexopyranosyl)oxy]-14-ethyl-7,12,13-trihydroxy-3,5,7,9,11,13-hexamethyl-6-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]oxacyclotetradecane-2, 10-dione with a molecular formula of C37H67NO13 and a molecular weight of 733.94. The structural formula is as follows:

Erythromycin Topical Solution USP 2% contains 20 mg/mL of erythromycin base in a vehicle consisting of alcohol (66%), propylene glycol, and citric acid to adjust pH.

CLINICAL PHARMACOLOGY:

Although the mechanism by which Erythromycin Topical Solution acts in reducing inflammatory lesions of acne vulgaris is unknown, it is presumably due to its antibiotic action.

INDICATIONS AND USAGE:

Erythromycin Topical Solution is indicated for the topical control of acne vulgaris.

CONTRAINDICATIONS:

Erythromycin Topical Solution is contraindicated in persons who have shown hypersensitivity to erythromycin or any of the other listed ingredients.

WARNINGS:

The safe use of Erythromycin Topical Solution during pregnancy or lactation has not been established.

PRECAUTIONS:

General:

The use of antibiotic agents may be associated with the overgrowth of antibiotic-resistant organisms. If this occurs, administration of this drug should be discontinued and appropriate measures taken.

Information for Patients:

Erythromycin Topical Solution is for external use only and should be kept away from the eyes, nose, mouth and other mucous membranes. Concomitant topical acne therapy s...