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Erythromycin and sulfisoxazole
  • Treatments
  • Otitis Media

Erythromycin and sulfisoxazole (Oral)

Medically reviewed by Drugs.com. Last updated on Mar 1, 2022.

Commonly used brand name(s)

In the U.S.

  • E.S.P.
  • Eryzole
  • Pediazole

Chemical Class: Erythromycin

Uses for erythromycin and sulfisoxazole

Erythromycin and sulfisoxazole is a combination antibiotic used to treat ear infections in children. It also may be used for other problems as determined by your doctor. It will not work for colds, flu, or other virus infections.

Erythromycin and sulfisoxazole combination is available only with your doctor's prescription.

Before using erythromycin and sulfisoxazole

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For erythromycin and sulfisoxazole, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to erythromycin and sulfisoxazole or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Erythromycin and sulfisoxazole has been tested in children over the age of 2 months and has not been shown to cause different side effects or problems than it does in adults. Erythromycin and sulfisoxazole should not be given to infants under 2 months of age unless directed by the child's doctor, because it may cause unwanted effects.

Geriatric

Erythromycin and sulfisoxazole is intended for use in children and is not generally used in adult patients.

Breastfeeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking erythromycin and sulfisoxazole, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using erythromycin and sulfisoxazole with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

  • Astemizole
  • Bepridil
  • Cisapride
  • Colchicine
  • Dihydroergotamine
  • Dronedarone
  • Eliglustat
  • Ergoloid Mesylates
  • Ergonovine
  • Ergotamine
  • Flibanserin
  • Fluconazole
  • Grepafloxacin
  • Levoketoconazole
  • Levomethadyl
  • Lomitapide
  • Lovastatin
  • Mesoridazine
  • Methenamine
  • Methylergonovine
  • Methysergide
  • Pimozide
  • Piperaquine
  • Posaconazole
  • Saquinavir
  • Simvastatin
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Using erythromycin and sulfisoxazole with any of the following medicines is usually not recommended, but may be requi...