Acalabrutinib
Generic name: acalabrutinib [ a-KAL-a-BROO-ti-nib ]
Brand name: Calquence
Dosage form: oral capsule (100 mg)
Drug class:BTK inhibitors
What is acalabrutinib?
Acalabrutinib blocks the action of certain enzymes in the body, which can interfere with the growth and spread of cancer cells.
Acalabrutinib is used to treat mantle cell lymphoma (a type of non-Hodgkin lymphoma) in adults. acalabrutinib is given after other treatments have failed.
Acalabrutinib was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, patients responded to this medicine. However, further studies are needed.
Acalabrutinib may also be used for purposes not listed in this medication guide.
Warnings
This medicine can make it easier for you to bleed. Contact your doctor or seek emergency medical attention if you have any bleeding that will not stop.
Call your doctor at once if you have signs of bleeding inside your body, such as:dizziness, weakness, confusion, headache, speech problems, black or bloody stools, pink or brown urine, or coughing up blood or vomit that looks like coffee grounds.
Before taking this medicine
You should not use acalabrutinib if you are allergic to it.
To make sure acalabrutinib is safe for you, tell your doctor if you have ever had:
an active or chronic infection;
a heart rhythm disorder;
bleeding problems; or
hepatitis B (acalabrutinib can cause this condition to come back or get worse).
Taking acalabrutinib may increase your risk of developing other types of cancer, such as skin cancer. Talk to your doctor about this risk and what skin symptoms to watch for.
It is not known whether acalabrutinib will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether acalabrutinib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using acalabrutinib, and for at least 2 weeks after your last dose.
How should I take acalabrutinib?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Acalabrutinib is usually taken once every 12 hours until your body no longer responds to the medicine.
Take this medicine with a full glass of water.
You may take acalabrutinib with or without food.
Do not chew, break, or open the acalabrutinib capsule. Swallow it w...
