Aleve PM

Generic name:diphenhydramine and naproxen [ DYE-fen-HYE-dra-meen-and-na-PROX-en ]
Drug class:Analgesic combinations

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 2, 2021.

What is Aleve PM?

Aleve PM contains a combination of diphenhydramine and naproxen. Diphenhydramine is an antihistamine. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID).

Aleve PM is used to treat occasional insomnia associated with minor aches and pains. This medicine is not for use in treating sleeplessness without pain, or sleep problems that occur often.

Aleve PM is for use in adults and children at least 12 years old.

Warnings

Use Aleve PM exactly as directed. Taking too much diphenhydramine can lead to serious heart problems, seizures, coma, or death.

Naproxen can increase your risk of fatal heart attack or stroke. Do not use Aleve PM just before or after heart bypass surgery (coronary artery bypass graft, or CABG). Naproxen may also cause stomach or intestinal bleeding, which can be fatal.

Before taking this medicine

Naproxen can increase your risk of fatal heart attack or stroke, even if you don't have any risk factors. Do not use Aleve PM just before or after heart bypass surgery (coronary artery bypass graft, or CABG).

Naproxen may also cause stomach or intestinal bleeding, which can be fatal. These conditions can occur without warning while you are using Aleve PM, especially in older adults.

You should not use Aleve PM if you are allergic to diphenhydramine or naproxen, or if you have ever had an asthma attack or severe allergic reaction after taking aspirin or an NSAID.

Ask a doctor or pharmacist if Aleve PM is safe to use if you have ever had:

• heart disease, high blood pressure;

• a heart attack, stroke, or blood clot;

• stomach ulcers or bleeding;

• a breathing problem, such as asthma, emphysema, or bronchitis;

• liver or kidney disease;

• glaucoma;

• enlarged prostate or problems with urination; or

• if you take aspirin to prevent heart attack or stroke.

Ask a doctor before using this medicine if you are pregnant or plan to become pregnant.

If you are pregnant, you should not take Aleve PM unless your doctor tells you to. Taking an NSAID during the last 20 weeks of pregnancy can cause serious heart or kidney problems in the unborn baby and possible complications with your pregnancy.

Ask a doctor before using this medicine if you are breast...