ExeClear-C
Generic name:codeine phosphate and guaifenesin
Dosage form: syrup
Drug class:Upper respiratory combinations
Medically reviewed by Drugs.com. Last updated on Jan 24, 2022.
Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.
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ExeClear-C Description
ExeClear-C Syrup is a clear, colorless liquid with a fruit gum flavor for oral administration.
Each teaspoon (5 ml) of ExeClear-C Syrup contains:
Codeine* Phosphate USP …………………. 10 mg
(*Warning: May be habit Forming)
Guaifenesin USP ………………………………. 200 mg
Codeine phosphate has the chemical name 7, 8-Didehydro-4,5α-epoxy-3-methoxy-17-methylmorphinan-6α-ol phosphate (1:1) (salt) hemihydrate. Its molecular formula is C18H21NO3H3PO4 • ½H2O with a molecular weight of 406.37. It occurs as fine, white, needle-shaped crystals, or white, crystalline powder. It is freely soluble in water at 25°C; slightly soluble in ethanol. Following absorption codeine is metabolized by the liver and metabolic products are excreted in the urine. Its structure is as follows:
Guaifenesin has the chemical name 3-(2-methoxyphenoxy)-1,2-propanediol. Its molecular formula is C10H14O4, with a molecular weight of 198.21. It is a white or slightly gray crystalline substance with a slightly bitter aromatic taste. One gram dissolves in 20 mL water at 25°C; freely soluble in ethanol. Guaifenesin is readily absorbed from the GI tract and is rapidly metabolized and excreted in the urine. Guaifenesin has a plasma half-life of one hour. The major urinary metabolite is beta-(2-methoxyphenoxy) lactic acid. Its structure is as follows:
