Exefen IR Tablets

Generic name:pseudoephedrine hydrochloride and guaifenesin
Dosage form: tablet
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

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Rx Only

Exefen IR Tablets Description

Each immediate-release tablet for oral administration contains:

Pseudoephedrine HCl 60 mg
Guaifenesin 400 mg

Inactive ingredients

Croscarmellose Sodium, Magnesium Stearate, Maltodextrin, Microcrystalline Cellulose, Polyvinylpyrrolidone, Silica and Stearic Acid.

Pseudoephedrine hydrochloride is an adrenergic (vasoconstrictor) which occurs as fine, white to off white crystals or powder, having a faint characteristic odor. It is very soluble in water, freely soluble in alcohol and sparingly soluble in chloroform. The chemical name is benzenemethanol, α - [1-(methylamino) ethyl]-, [S-(R*,R*)]-, hydrochloride. The structural formula is:

Guaifenesin is an expectorant and occurs as a white to slightly gray, crystalline powder, having a bitter taste. It may have a slight characteristic odor. It is soluble in water, in alcohol, in chloroform, in glycerin and in propylene glycol. The chemical name is: 1,2 propanediol, 3-(2-methoxyphenoxy)-. Chemically, Guaifenesin is 1,2-Propanediol, 3-(2-methoxyphenoxy)-,(+) and has the following structural formula:

Exefen IR Tablets - Clinical Pharmacology

Pseudoephedrine

Pseudoephedrine acts as an indirect sympathomimetic agent by stimulating sympathetic (adrenergic) nerve endings to release norepinephrine. Norepinephrine in turn stimulates alpha and beta receptors throughout the body. The action of pseudoephedrine is apparently more specific for the blood vessels of the upper respiratory tract and less specific for the blood vesse..