Fibrinogen/
Medically reviewed by Drugs.com. Last updated on May 31, 2022.
Commonly used brand name(s)
In the U.S.
- Artiss
- Tisseel
Available Dosage Forms:
- Solution
Uses for fibrinogen/aprotinin and thrombin/calcium chloride
Aprotinin, calcium chloride, fibrinogen, and thrombin combination is used to help control bleeding during surgery when other procedures to close a wound or incision, such as stitches, bands, and heat cannot be used. It is also used to help skin tissues stick together during skin graft or cosmetic surgery (eg, burn treatment or facelift procedures). Fibrinogen/aprotinin and thrombin/calcium chloride is a fibrin sealant.
Artiss™ and Tisseel™ contain man-made proteins (aprotinin, fibrinogen, and thrombin) that are used to stop bleeding by helping the blood to clot.
Fibrinogen/aprotinin and thrombin/calcium chloride is to be given only by or under the supervision of your doctor.
Before using fibrinogen/aprotinin and thrombin/calcium chloride
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For fibrinogen/aprotinin and thrombin/calcium chloride, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to fibrinogen/aprotinin and thrombin/calcium chloride or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Artiss™ and Tisseel™ in children.
Geriatric
Appropriate studies on the relationship of age to the effects of Artiss™ have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Tisseel™ in the elderly.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
