Flunisolide

Dosage form: nasal spray
Drug class:Nasal steroids

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Rx only

FOR INTRANASAL USE ONLY

DESCRIPTION

Flunisolide Nasal Solution, USP 0.025% is intended for administration as a spray to the nasal mucosa. Flunisolide, the active component of Flunisolide Nasal Solution, is an anti-inflammatory steroid.

Flunisolide is represented by the following structural formula:

C24H31FO6 • 1/2H2O

Mol. Wt. 443.52

Chemical Name:

6α-fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone (USAN).

Flunisolide is a white to creamy white crystalline powder. It is soluble in acetone, sparingly soluble in chloroform, slightly soluble in methanol, and practically insoluble in water. It has a melting point of about 245°C.

After initial priming (5 to 6 sprays), each spray of the unit delivers a metered droplet spray of 100 mg formulation containing 25 mcg of Flunisolide. The size of the droplets produced by the unit is in excess of 8 microns to facilitate deposition on ...