Fluorouracil Topical Solution

Dosage form: topical solution
Drug class:Topical antineoplastics

Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.

Rx only

FOR TOPICAL USE ONLY – NOT FOR OPHTHALMIC, ORAL OR INTRAVAGINAL USE

Fluorouracil Topical Solution Description

Fluorouracil Solutions are topical preparations containing the fluorinated pyrimidine 5-fluorouracil, an antineoplastic antimetabolite.

Fluorouracil Solution consists of 2% or 5% fluorouracil on a weight/weight basis, compounded with edetate disodium, hydroxypropyl cellulose, parabens (methyl and propyl), propylene glycol, purified water and tromethamine.

Chemically, fluorouracil is 5-fluoro-2,4(1-H,3H)-pyrimidinedione. It is a white to practically white, crystalline powder which is sparingly soluble in water and slightly soluble in alcohol. One gram of fluorouracil is soluble in 100 mL of propylene glycol. The molecular weight of 5-fluorouracil is 130.08 and the structural formula is:

Fluorouracil Topical Solution - Clinical Pharmacology

There is evidence that the metabolism of fluorouracil in the anabolic pathway blocks the methylation reaction of ...