Fluoxymesterone
Class: Androgens
ATC Class: G03BA01
VA Class: HS100
Chemical Name: 11β, 17β Androst-4-en-3-one, 9-fluoro-11, 17-dihydroxy-17 methyl
Molecular Formula: C20 H29 FO3
CAS Number: 76-43-7
Brands: Androxy
Introduction
Synthetic androgenic anabolic steroid hormone.
Uses for Fluoxymesterone
Male Hypogonadism
Management of congenital or acquired primary hypogonadism such as that resulting from orchiectomy or from testicular failure caused by cryptorchidism, bilateral torsion, orchitis, or vanishing testis syndrome.
Management of congenital or acquired hypogonadotropic hypogonadism such as that resulting from idiopathic gonadotropin or gonadotropin releasing hormone (luteinizing hormone releasing hormone) deficiency or from pituitary-hypothalamic injury caused by tumors, trauma, or radiation.
If any of these conditions occur before puberty, androgen replacement therapy will be necessary during adolescence for the development of secondary sexual characteristics; prolonged therapy required to maintain these characteristics. Prolonged androgen therapy also required to maintain sexual characteristics in other males who develop testosterone deficiency after puberty.
May be used to stimulate puberty in carefully selected males with delayed puberty (family history of delayed puberty not secondary to a pathologic disorder). Brief treatment with conservative doses of an androgen occasionally may be justified in these males if they do not respond to psychologic support.
Breast Cancer
Palliative treatment of androgen-responsive, advanced, inoperable, metastatic (skeletal) breast cancer in women who are 1–5 years postmenopausal and in premenopausal women who have benefited from oophorectomy and are considered to have a hormone-responsive tumor.
Poorly tolerated (see Virilization under Cautions); other hormonal agents (e.g., tamoxifen, anastrozole, letrozole, exemestane) currently are preferred for this use.
Misuse, Abuse, and Dependence
Has been misused and abused by athletes, bodybuilders, weight lifters, and others to enhance athletic performance and physique†.
Based on review of data, FDA concluded that misuse and abuse of androgens associated with serious adverse cardiovascular, hepatic, endocrine, and mental health effects. (See Misuse, Abuse, and Dependence under Cautions.)
Medical and sport experts (e.g., International Olympic Committee) consider such use to be inappropriate and unacceptable because of known adverse effects and potential for long-term sequelae. Such use by athletes is contrary to the rules and ethical principles of athletic competition.
Evaluate serum testosterone concentrations if misuse or abuse of androgens suspected (e.g., patients experiencing serious adverse cardiovascular or psychiatric effects). Serum testosterone concentrations may be below or within the normal range in patients abusing synthetic derivatives of testosterone.
