Flurandrenolide Ointment

Dosage form: ointment
Drug class:Topical steroids

Medically reviewed by Drugs.com. Last updated on Sep 21, 2021.

Flurandrenolide Ointment Description

Flurandrenolide, USP is a potent corticosteroid intended for topical use. Flurandrenolide occurs as white to off-white, fluffy, crystalline powder and is odorless. Flurandrenolide is practically insoluble in water and in ether. One gram of flurandrenolide dissolves in 72 mL of alcohol and in 10 mL of chloroform. The molecular weight of flurandrenolide is 436.52.

The chemical name of flurandrenolide is Pregn-4-ene-3,20-dione,6-fluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]-. (6α, 11β, 16α)-; its empirical formula is C24H33FO6. The structure is as follows:

Flurandrenolide Chemical Structure

Each gram of Flurandrenolide Ointment USP, 0.05% contains 0.5 mg (1.145 µmol; 0.05%) flurandrenolide in a base composed of white wax, cetyl alcohol, sorbitan sesquioleate, and white petrolatum.

Flurandrenolide Ointment - Clinical Pharmacology

Flurandrenolide is primarily effective because of its anti-inflammatory, antipruritc and vasoconstrictive actions.

The mechanism of the anti-inflammatory effect of the topical corticosteroids is not completely understood. Corticosteroids with anti-inflammatory activity may stabilize cellular and lysosomal membranes. There is also the suggestion that the effect on the membranes of lysosomes prevents the release of proteolytic enzymes and, thus, plays a part in reducing inflammation.

Pharmacokinetics

The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/o...