Gengraf (Oral)
Generic name:cyclosporine (oral route) [ sye-kloe-SPOR-een ]
Drug class:Calcineurin inhibitors
Medically reviewed by Drugs.com. Last updated on May 23, 2022.
Only physicians experienced in management of systemic immunosuppressive therapy for the indicated disease should prescribe Sandimmune(R) (cycloSPORINE) and Neoral(R) (cycloSPORINE, modified). CycloSPORINE should be administered with adrenal corticosteroids but not with other immunosuppressive agents. Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. CycloSPORINE and cycloSPORINE, modified are not bioequivalent and cannot be used interchangeably without physician supervision. CycloSPORINE absorption is erratic during chronic administration of Sandimmune(R) capsules and oral solution. Monitor cycloSPORINE blood levels to avoid toxicity due to high concentrations and possible organ rejection due to low levels .
Oral route(Capsule, Liquid Filled;Solution)Only physicians experienced in management of systemic immunosuppressive therapy for the indicated disease should prescribe cycloSPORINE, modified. Increased susceptibility to infection and the possible development of lymphoma may result from immunosuppression. Hypertension and nephrotoxicity can occur at recommended dosages, and the risk increases with increasing dose and duration of cycloSPORINE therapy. Monitor blood levels and renal function to avoid toxicity. CycloSPORINE, modified (Neoral(R) or Gengraf(R)) and cycloSPORINE (Sandimmune(R)) are not bioequivalent and cannot be used interchangeably without physician supervision. Psoriasis patients previously treated with PUVA and to a lesser extent, methotrexate or other immunosuppressive agents, UV-B, coal tar, or radiation therapy, are at an increased risk of developing skin malignancies when taking cycloSPORINE .
Commonly used brand name(s)
In the U.S.
- Gengraf
- Neoral
- SandIMMUNE
In Canada
- Apo-cycloSPORINE
Available Dosage Forms:
- Capsule, Liquid Filled
- Solution
- Capsule
Therapeutic Class: Immune Suppressant
Pharmacologic Class: Calcineurin Inhibitor
Uses for Gengraf
Cyclosporine is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). It belongs to a group of medicines known as immunosuppressive agents.
When a patient receives an organ transplant, the body's white blood cells will try to get rid of (reject) the transplanted organ. Cyclosporine works by suppressing the immune system to prevent the white blood cells from trying to get rid of the transplanted organ.
Cyclosporine is also used to treat severe rheumatoid arthritis in patients who have failed treatment with methotrexate. This medicine is also used to treat adults with severe plaque psoriasis after other treatments (eg, PUVA, retinoids, methotrexate) failed.
Cyclosporine is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doct
