GentaVed

Generic name: gentamicin sulfate and betamethasone valerate
Dosage form: FOR ANIMAL USE ONLY

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GentaVed
Topical Spray

(GENTAMICIN SULFATE WITH
BETAMETHASONE VALERATE)

TOPICAL SPRAY
VETERINARY

Net Contents: 60 mL

VEDCO

Caution: Federal law restricts this
drug to use by or on the order of
a licensed veterinarian.

ANADA 200-388, Approved by FDA

Each mL contains: gentamicin sulfate
equivalent to 0.57 mg gentamicin base,
betamethasone valerate equivalent to
0.284 mg betamethasone, 163 mg
isopropyl alcohol, propylene glycol,
methylparaben and propylparaben as
preservatives, purified water q.s.
Hydrochloric acid may be added to adjust pH.

For topical use in dogs only.

Usual dose: Two depressions of the
sprayer head 2 to 4 times daily for 7 days.

Keep out of Reach of Children.
For animal use only.

Read accompanying directions carefully.
Store upright between 2oC and 30oC
(36oF and 86oF)

Manufactured For
VEDCO, INC.
St. Joseph, MO 64507

Description

DESCRIPTION: Each mL contains: gentamicin sulfate equivalent to 0.57 mg
gentamicin base, betamethasone valerate equivalent to 0.284 mg betamethasone,
163 mg isopropyl alcohol, propylene glycol, methylparaben and propylparaben as
preservatives, purified water q.s. Hydrochloric acid may be added to adjust pH.

Chemistry, Pharmacology and Toxicity

CHEMISTRY: Gentamicin is a mixture of aminoglycoside antibiotics derived from the
fermentation of Micromonospora purpurea. Gentamicin sulfate is a mixture of sulfate
salts of the antibiotics produced in this fermentation. The salts are weakly acidic
and freely soluble in water.

Gentamicin sulfate contains not less than 500 micrograms of gentamicin base per
milligram.

Betamethasone valerate is a synthetic glucocorticoid.

PHARMACOLOGY: Gentamicin, a broad-spectrum antibiotic, is a highly
effective topical treatment for bacterial infection of the skin In vitro,
gentamicin is bactericidal against a wide variety of gram-positive and gram-
negative bacteria isolated from domestic animals. 1,2 Specifically, gentamicin is
active against the following organisms isolated from canine skin: Alcaligenes
sp., Citrobacter sp., Klebsiella sp., Pseudomonas aeruginosa, indole-positive
and -negative Proteus sp., Escherichia coli, Enterobacter sp., Staphlyococcus sp.
and Streptococcus sp.

Betamethasone valerate emerged from intensive