Gilteritinib
Generic name: gilteritinib [ GIL-te-RI-ti-nib ]
Brand name: Xospata
Dosage form: oral tablet (40 mg)
Drug class:Multikinase inhibitors
What is gilteritinib?
Gilteritinib is used to treat acute myeloid leukemia (AML) in adults with an abnormal FLT3 gene. Your doctor will test you for this gene.
Gilteritinib is given after other cancer treatments did not work or have stopped working.
Gilteritinib may also be used for purposes not listed in this medication guide.
Warnings
Gilteritinib can cause a condition called differentiation syndrome, which affects blood cells and can be fatal if not treated. This condition may occur within 2 days to 3 months after you start taking gilteritinib.
Seek medical help right away if you have symptoms of differentiation syndrome: fever, cough, trouble breathing, bone pain, rapid weight gain, or swelling in your arms, legs, underarms, groin, or neck.
Before taking this medicine
You should not use gilteritinib if you are allergic to it.
Tell your doctor if you have ever had:
heart problems;
long QT syndrome (in you or a family member); or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
Before you take gilteritinib, your heart function may need to be checked using an electrocardiograph or ECG (sometimes called an EKG).
Gilteritinib can harm an unborn baby or cause birth defects if the mother or the father is using this medicine.
If you are a woman, do not use gilteritinib if you are pregnant. You may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 6 months after your last dose.
If you are a man, use effective birth control if your sex partner is able to get pregnant. Keep using birth control for at least 4 months after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using gilteritinib.
Do not breastfeed while using this medicine, and for at least 2 months after your last dose.
How should I take gilteritinib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
You may need frequent medical tests to be sure this medicine is not causing harmful effects. Your cancer treatments may be delayed based on the results.
Gilteritinib is usually given once per day. Take this medicine with a full ...
