Givlaari
Generic name:givosiran [ gi-VOE-si-ran ]
Drug class:Miscellaneous metabolic agents
What is Givlaari?
Givlaari is used to treat acute hepatic porphyria in adults.
Acute hepatic porphyria is a rare genetic disorder that can cause life-threatening attacks on the nervous system. Symptoms include severe stomach pain, nausea and vomiting, numbness, weakness, or mental status changes. This disorder is more common in women during their child-bearing years.
Givlaari may also be used for purposes not listed in this medication guide.
Warnings
You will need frequent blood tests and your next dose may be delayed based on the results.
Before taking this medicine
You should not use Givlaari if you are allergic to it.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether Givlaari will harm an unborn baby. However, having acute hepatic porphyria during pregnancy may cause serious medical problems in both mother and baby. The benefit of treating this disorder may outweigh any risks to the baby.
It may not be safe to breastfeed while using Givlaari. Ask your doctor about any risk.
How should I take Givlaari?
Follow all directions and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.
Givlaari is injected under the skin, usually once per month.
A healthcare provider will give you this injection.
You will need frequent blood tests to check your liver function before and during treatment with Givlaari. Your next dose may be delayed based on the results.
Your kidney function may also need to be checked.
Givlaari doses are based on weight. Your dose needs may change if you gain or lose weight.
What happens if I miss a dose?
Get the missed injection as soon as possible, and then go back to your regular injection schedule. Do not use two doses at one time.
What happens if I overdose?
Since Givlaari is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.
