Glasdegib
Generic name: glasdegib [ glas-DEG-ib ]
Brand name: Daurismo
Dosage form: oral tablet (100 mg; 25 mg)
Drug class:Hedgehog pathway inhibitors
What is glasdegib?
Glasdegib is used in combination with cytarabine to treat acute myeloid leukemia. This combination is for use in adults who are 75 years or older, or who cannot use standard chemotherapy due to other medical conditions.
Glasdegib may also be used for purposes not listed in this medication guide.
Warnings
Glasdegib can cause severe birth defects or death of a baby if the mother or the father is taking glasdegib at the time of conception or during pregnancy. Both men and women should use effective birth control to prevent pregnancy while using this medicine and for at least 30 days after your last dose.
Before taking this medicine
Glasdegib can cause severe birth defects or death of a baby if the mother or the father is taking this medicine at the time of conception or during pregnancy.
If you are a woman who is able to get pregnant, you may need to have a negative pregnancy test before starting this treatment. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 30 days after your last dose.
If you are a man, use condoms when having sex with a woman who is able to get pregnant, even if you have had a vasectomy. Keep using condoms for at least 30 days after your last dose.
Tell your doctor right away if a pregnancy occurs while either the mother or the father is using glasdegib.
This medicine may affect fertility (ability to have children) in men. However, it is important to use birth control to prevent pregnancy because glasdegib can harm an unborn baby.
Do not breastfeed while using this medicine, and for at least 30 days after your last dose.
Tell your doctor if you have ever had:
heart problems;
long QT syndrome (in you or a family member); or
an electrolyte imbalance (such as low levels of potassium or magnesium in your blood).
How should I take glasdegib?
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Glasdegib is given in a 28-day treatment cycle, usually for a total of 6 cycles. Glasdegib is taken by mouth, and cytarabine is given as an injection under your skin. Your doctor will determi...
