Glecaprevir and pibrentasvir
Generic name: glecaprevir and pibrentasvir [ glec-A-pre-vir-and-pi-BRENT-as-vir ]
Brand name: Mavyret
Dosage forms: oral pellet (50 mg-20 mg); oral tablet (100 mg-40 mg)
Drug class:Antiviral combinations
What is glecaprevir and pibrentasvir?
Glecaprevir and pibrentasvir is a combination antiviral medicine used to treat chronic hepatitis C in people with HCV genotype 1, 2, 3, 4, 5, or 6.
Glecaprevir and pibrentasvir is usually given after other treatments have failed.
Glecaprevir and pibrentasvir may also be used for purposes not listed in this medication guide.
Warnings
You should not use glecaprevir and pibrentasvir if you have severe liver disease, or if you also take atazanavir or rifampin.
If you've ever had hepatitis B, it may become active or get worse after you stop using glecaprevir and pibrentasvir. You may need frequent liver function tests for several months.
Before taking this medicine
You should not use this medicine if you are allergic to glecaprevir or pibrentasvir, or if:
you have liver disease; or
you also take atazanavir or rifampin.
Tell your doctor if you have ever had:
hepatitis B;
liver problems other than hepatitis;
a liver or kidney transplant;
HIV (human immunodeficiency virus); or
an opioid addiction or past use of injected drugs.
Tell your doctor if you are pregnant or breastfeeding.
Glecaprevir and pibrentasvir should not be given to a child younger than 3 years old.
How should I take glecaprevir and pibrentasvir?
Your doctor will perform blood tests to make sure you do not have conditions that would prevent you from safely using glecaprevir and pibrentasvir.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.
You should not stop using glecaprevir and pibrentasvir suddenly. Stopping suddenly could make your condition harder to treat with hepatitis C antiviral medicine.
Use all hepatitis C medications as directed and read all medication guides you receive. Do not change your dose or stop using a medicine without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor.
If you've ever had hepatitis B, this virus may become active or get worse in the months after you stop using glecaprevir and pibrentasvir. You may need frequent
