Granisol
Generic name:granisetron hydrochloride
Dosage form: oral solution
Drug class:5HT3 receptor antagonists
Medically reviewed by Drugs.com. Last updated on Oct 22, 2021.
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The Granisol brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available.
Granisol Description
Granisol™ Oral Solution contains granisetron hydrochloride, an antinauseant and antiemetic agent. Chemically it is endo-N-(9-methyl-9-azabicyclo [3.3.1] non-3-yl)-1-methyl-1H-indazole-3-carboxamide hydrochloride with a molecular weight of 348.9 (312.4 free base). Its empirical formula is C18H24N4O•HCl, while its chemical structure is:
granisetron hydrochloride
Granisetron hydrochloride is a white to off-white solid that is readily soluble in water and normal saline at 20°C.
Oral Solution
Each 10 mL of clear, orange-colored, orange-flavored Granisol™ Oral Solution contains 2.24 mg of granisetron hydrochloride equivalent to 2 mg granisetron. Inactive ingredients: citric acid anhydrous, FD&C Yellow No. 6, orange flavor, purified water, sodium benzoate, and sorbitol.
Granisol - Clinical Pharmacology
Granisetron is a selective 5-hydroxytryptamine3 (5-HT3) receptor antagonist with little or no affinity for other serotonin receptors, including 5-HT1; 5-HT1A; 5-HT1B/C; 5-HT2; for alpha1-, alpha2-, or beta-adrenoreceptors; for dopamine-D2; or for histamine-H1; benzodiazepine; picrotoxin or opioid receptors.
Serotonin receptors of the 5-HT3 type are located peripherally on vagal nerve terminals and centrally in the chemorece...
