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Guaifenesin
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Guaifenesin

Generic name: guaifenesin [ gwye-FEN-e-sin ]
Brand names: Mucinex, Robitussin Mucus + Chest Congestion, Triaminic Chest Congestion, Tussin Expectorant, Xpect, Organidin NR, Bidex 400
Drug class:Expectorants

Medically reviewed by Melisa Puckey, BPharm. Last updated on May 16, 2022.

What is guaifenesin?

Guaifenesin is an ingredient in cough and cold medicines that is used to help clear mucus or phlegm from your chest when you have had a cold or flu. Guaifenesin works by making your mucus thinner and easier to cough up, which helps clear chest congestion. Guaifenesin is available as an over-the-counter (OTC) medicine and also available on prescription.

Guaifenesin is not FDA approved for treatment of fibromyalgia but some people take it off-label for this condition.  In clinical studies guaifenesin has not shown to be effective for fibromyalgia.

Warnings

You should not use this medicine if you are allergic to guaifenesin.

Use this medicine exactly as directed on the label, or as prescribed by your doctor. Do not use it in larger amounts or for longer than recommended.

Guaifenesin is commonly found as part of over-the-counter combination medications for cold and cough. Read labels or ask a doctor or pharmacist before using any other cold, or cough medicine when taking guaifenesin.

Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

Drink extra fluids to help loosen the congestion and lubricate your throat while you are taking this medication. This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

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