Guaifenesin-DM NR

Generic name: guaifenesin and dextromethorphan hydrobromide
Dosage form: liquid
Drug class:Upper respiratory combinations

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Disclaimer: This drug has not been found by FDA to be safe and effective, and this labeling has not been approved by FDA. For further information about unapproved drugs, click here.

Guaifenesin-DM NR Description

Guaifenesin-DM NR Liquid is a clear yellow liquid with a raspberry flavor.
Each 5 mL (1 teaspoonful) contains:
Guaifenesin 100 mg.
Dextromethorphan Hydrobromide 10 mg.

Other Ingredients: Citric Acid, D&C Yellow No. 10, FD&C Red No. 40, Glycerin, Methylparaben, Propylene Glycol, Raspberry Flavor, Saccharin Sodium, Sodium Benzoate, Sorbitol Solution, Water. It may contain Sodium Citrate. Guaifenesin (glyceryl guaiacolate) has the chemical name 3-(2-methoxyphenoxy)-1,2-propanediol. Its molecular formula is C10H14O4, with a molecular weight of 198.21. It is a white, colorless crystalline substance with a slightly bitter aromatic taste. One gram dissolves in 20 mL water at 25°C; freely soluble in ethanol. Guaifenesin is readily absorbed from the GI tract and is rapidly metabolized and excreted in the urine. Guaifenesin has a plasma halflife of one hour. The major urinary metabolite is beta-(2-methoxyphenoxy) lactic acid.

Guaifenesin-DM NR - Clinical Pharmacology

Guaifenesin-DM NR LIQUID combines the expectorant, guaifenesin and the cough suppressant, dextromethorphan hydrobromide. Guaifenesin is an expectorant, the action of which promotes or facilitates the removal of secretions from the respiratory tract. By increasing sputum volume and making sputum less viscous, guaifenesin facilitates expectoration of retained secretions. Dextromethorphan is a synthetic nonopioid cough suppressant, the dextro isomer of the codeine analogue of levorphanol. Dextromethorphan acts centrally to elevate the threshold for coughing, but does not have addictive, analgesic or sedative actions and does not produce respiratory depression with usual doses.

Indications and Usage for Guaifenesin-DM NR

Temporarily relieves cough due to minor throat and bronchial irritation as may occur with the common cold or inhaled irritants. Calms the cough control center and relieves coughing. Helps loosen phlegm (mucus) and thin bronchial se