Holly

Scientific Name(s): Ilex aquifolium L. (English Holly)., Ilex opaca Aiton. (American Holly)., Ilex vomitoria Aiton. (Yaupon).
Common Name(s): American holly, Appalachian tea, Cassena, Christmas berry, Deer berry, English holly, Holly, Indian black drink, Indian holly, Oregon holly, Yaupon

Medically reviewed by Drugs.com. Last updated on Aug 23, 2021.

Clinical Overview

Use

Primarily used as a holiday decoration. No clinical applications exist for holly. Historically, some species have been used in teas as an emetic and CNS stimulant.

See also monograph for related 'Maté' species (Ilex paraguariensis A. St.-Hil. var.) for which limited clinical studies have been conducted.

Dosing

There are no clinical applications for holly to form a basis for dosing.

Contraindications

Contraindications have not yet been identified.

Pregnancy/Lactation

Documented adverse effects. Avoid use.

Interactions

None well documented.

Adverse Reactions

The spines of some leaves may tear or puncture skin or mucus membranes.

Toxicology

Although no fatalities have been reported, case reports exist of human toxicity. Ingestion can cause vomiting or diarrhea, and may lead to dehydration and electrolyte imbalance. Stupor has been associated with poisoning.

Scientific Family

• Aquifoliaceae (Holly)

Botany

Ilex species are evergreen trees or shrubs with stiff leathery leaves. The flowers are often white and produce fruits that range in color from black to bright red or yellow. The genus Ilex consists of over 400 species and requires a wet and equable climate. Worldwide distribution exists, except in arctic or arid regions. The major areas of distribution are Central and South America. The North American species are largely ornamental and derived from Central and South American varieties.PLANTS.Ilex.2017, Alikaridis 1987

See also Maté monograph (Ilex paraguariensis A. St.-Hil. var.).

History

The plants in the holly family have been used as ornamentals and in herbal medicine for centuries. Historical records show pre-Christian European pagans offering holly branches as gifts during the Roman festival of Saturnalia. Early Christians decorated their homes with holly during the Christmas season, a practice that still continues today. Settlers in the southeastern United States made yaupon tea from I. vomitoria, reserving a stronger decoction for use as an emetic. I. opaca fruit tea was used as a cardiac stimulant by the American Indians; the Chinese used it to treat coronary disease. One of the most economically important species, Ilex paraguayensis or maté tea (see the Maté monograph), has long been cultivated and used in Brazil and Paraguay as a caffeine-containing beverage. The mixed leaves of Ilex cassine, I. vomitoria, and Ilex dahoon have also been used for a hot drink called yaupon or black drink. Drinkers used it ceremonially to "cleanse" themselves, probably due to its sweat- and vomit-inducing effects. Another beverage made from the leaves of I. cassine and I. vomitoria was used as a stimulant in the southern United States during the Civil War.Alikaridis 1987, PLANTS.Yaupon.2017

Chemistry

Most species contain tannins. Analyses of the leaves of I. aquifolium found tannic acid, a bitter glycoside (ilicin), ilexanthin (rutin), and ilicic acid. Some members of the genus, such as I. paraguayensis, contain xanthine alkaloids, such as caffeine, in levels as high as 2%. Other species contain saponins and triterpenes. One review of the chemistry of Ilex documented hundreds of isolated compounds. Se...