Homatropine
Class: Mydriatics
ATC Class: S01FA05
VA Class: OP600
CAS Number: 51-56-9
Brands: Homatropaire, Isopto Homatropine
Introduction
Mydriatic and cycloplegic; tertiary amine antimuscarinic.
Uses for Homatropine
Ophthalmologic Examination
Used to produce mydriasis and cycloplegia for refraction. However, because homatropine has prolonged mydriatic and relatively weak cycloplegic effects, other antimuscarinics may be preferred.
Ophthalmic Inflammation
Management of acute inflammatory conditions (e.g., iridocyclitis) of the uveal tract.
Perioperative Mydriasis
Used for pre- and postoperative states when mydriasis is required.
Axial Lens Opacities
Used as an optical aid in some cases of axial lens opacities.
Homatropine Dosage and Administration
General
Prior to initiation of therapy, estimate depth of the angle of the anterior chamber to avoid induction of angle-closure glaucoma in susceptible patients.
Administration
Ophthalmic Administration
Apply topically to eye(s) as an ophthalmic solution.
For topical ophthalmic use only. Not for injection.
Following topical application, apply finger pressure on lacrimal sac for 2–3 minutes to avoid excessive systemic absorption.
Avoid contamination of solution container.
Dosage
Available as homatropine hydrobromide; dosage expressed in terms of the salt.
In patients with heavily pigmented irides, higher dosages may be required.
Pediatric Patients
Use only the 2% solution in pediatric patients.
Ophthalmologic Examination
Ophthalmic
1 drop of a 2% solution in the eye(s) immediately before the procedure; may repeat at 10-minute intervals as necessary.
Ophthalmic Inflammation
Ophthalmic
1 drop of a 2% solution in the eye(s) 2 or 3 times daily.
Adults
Ophthalmologic Examination
Ophthalmic
1 or 2 drops of a 2 or 5% solution in the eye(s) immediately before the procedure; may repeat in 5–10 minutes if necessary.
Ophthalmic Inflammation
Ophthalmic
1 or 2 drops of a 2 or 5% solution in the eye(s) 2 or 3 times daily or, if necessary, up to every 3–4 hours.
Special Populations
No special population dosage recommendations at this time.
Cautions for Homatropine
Contraindications
Known or suspected angle-closure (narrow-angle) glaucoma or a predisposition to angle-closure glaucoma.
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