Hydroxyprogesterone injection

Generic name: hydroxyprogesterone injection [ hye-DROX-ee-pro-JES-te-rone ]
Brand names: Makena, Makena Auto-Injector, Hylutin, Delta-Lutin, Duralutin, Hyprogesterone, Prodrox
Dosage forms: intramuscular solution (250 mg/mL); subcutaneous solution (275 mg/1.1 mL)
Drug class:Progestins

Medically reviewed by Drugs.com on Jun 18, 2021. Written by Cerner Multum.

What is hydroxyprogesterone?

Hydroxyprogesterone is a form of progestin, a manmade form of a female hormone called progesterone.

Hydroxyprogesterone is used to lower the risk of premature birth in a woman who has already had one premature baby. Hydroxyprogesterone will not stop premature labor that has already begun.

Hydroxyprogesterone is not for use in women who are pregnant with more than one baby (twins, triplets, etc).

Hydroxyprogesterone may also be used for purposes not listed in this medication guide.

Warnings

You should not use hydroxyprogesterone injection if you have: uncontrolled high blood pressure, unusual vaginal bleeding, liver disease or liver cancer, jaundice caused by your pregnancy, or if you have ever had circulation problems, a stroke or blood clot, or cancer of the breast, uterus/cervix, or vagina.

Before taking this medicine

You should not be treated with this medicine if you are allergic to hydroxyprogesterone or castor oil, or if you have:

• unusual vaginal bleeding that is not related to your pregnancy;

• severe or uncontrolled high blood pressure;

• liver disease or liver cancer;

• jaundice caused by your pregnancy;

• a history of cancer of the breast, uterus/cervix, or vagina; or

• a history of a stroke, blood clot, or circulation problems.

Hydroxyprogesterone is not approved for use by anyone younger than 16 years old.

Tell your doctor if you have ever had:

• eclampsia or preeclampsia of pregnancy;

• kidney disease;

• high blood pressure, heart disease;

• migraine headaches;

• diabetes (in you or a family member);

• epilepsy or other seizure disorder;

• asthma; or

• depression.

It is not known whether hydroxyprogesterone will prevent any medical problems in a newborn baby. Talk to your doctor about your baby's individual risk.