Hylenex Recombinant

Generic name: hyaluronidase recombinant human
Dosage form: injection, solution
Drug class:Miscellaneous uncategorized agents

Medically reviewed by Drugs.com. Last updated on Apr 1, 2021.

Indications and Usage for Hylenex Recombinant

Subcutaneous Fluid Administration

Hylenex Recombinant is indicated as an adjuvant in subcutaneous fluid administration for achieving hydration.

Dispersion and Absorption of Injected Drugs

Hylenex Recombinant is indicated as an adjuvant to increase the dispersion and absorption of other injected drugs.

Subcutaneous Urography

Hylenex Recombinant is indicated as an adjunct in subcutaneous urography for improving resorption of radiopaque agents.

Hylenex Recombinant Dosage and Administration

Important Administration Instructions

Hylenex Recombinant should not be administered intravenously. Its effects relative to dispersion and absorption of other drugs are not produced when it is administered intravenously because the enzyme is rapidly inactivated.

Hylenex Recombinant may be administered for infiltration use, interstitial use, intramuscular use, intraocular use, peribulbar use, retrobulbar use, soft tissue use or subcutaneous use.

Visually inspect parenteral drug products for particulate matter and discoloration prior to administration.

Always use aseptic precautions. Lightly pinch the skin up into a small mound and insert the needle/catheter into the subcutaneous space. Inject Hylenex Recombinant through the catheter hub or injection port closest to the needle/catheter. Begin administration of solution. Solution should start in readily.

Subcutaneous Fluid Administration

Inject 150 U of Hylenex Recombinant prior to start of subcutaneous fluid administration to facilitate absorption of up to 1,000 mL or more of solution. As with all parenteral fluid therapy, observe effect closely, with the same precautions for restoring fluid and electrolyte balance as in intravenous injections. The dose, the rate of injection, and the type of solution (sa...