Hypaque-76

Generic name:diatrizoate meglumine and diatrizoate sodium
Dosage form: Injection, USP 76%
Drug class:Ionic iodinated contrast media

Medically reviewed by Drugs.com. Last updated on Mar 22, 2022.

Sterile Aqueous Injection

For Excretory Urography
Aortography
Angiocardiography (Ventriculography, Pulmonary
Angiography, Selective Coronary Arteriography)
Peripheral Angiography (Peripheral Arteriography
and Peripheral Venography)
Intravenous Digital Arteriography
Contrast Enhancement of Computed
Tomographic Head Imaging
Contrast Enhancement of Computed
Tomographic Body Imaging
Selective Renal Arteriography
Selective Visceral Arteriography
Central Venography
Renal Venography

Hypaque-76 Description

Hypaque-76, brand of diatrizoate meglumine and diatrizoate sodium, is a water-soluble, radiopaque diagnostic medium. It is supplied as a 76 percent sterile aqueous solution providing 66 percent (w/v) diatrizoate meglumine and 10 percent (w/v) diatrizoate sodium. It is a triiodinated benzoic acid derivative containing 37 percent (w/v) organically bound iodine. Each mL contains 370 mg iodine and 3.68 mg (0.16 mEq) sodium. It is constituted as a radiopaque iodinated anion, diatrizoate, and the radiolucent cations meglumine and sodium. It is the organically bound iodine of the anion which opacifies internal structures for x-ray visualization and fluoroscopy.

The solution is hypertonic to blood with an osmolality of 2016 mosm/kg (determined by VPO). The viscosity is 9 cp at 37° C. The pH is adjusted between 6.0 and 7.7 using Na2CO3 with HCl or NaOH. The pKa is 3.4 for diatrizoic acid. Edetate calcium disodium 0.01 percent has been added as a sequestering stabilizing agent. The solution is clear, colorless to pale yellow.

Diatrizoate meglumine is 1-deoxy-1-(methylamino)-D-glucitol 3, 5-diacetamido-2,4,6-triiodobenzoate (salt) and has the following structural formula:

Diatrizoate sodium is monosodium, 3, 5-diacetamido-2,4,