Indium In 111
Generic name: Indium In 111 chloride solution
Dosage form: injection, solution
Drug class:Diagnostic radiopharmaceuticals
Medically reviewed by Drugs.com. Last updated on Nov 22, 2021.
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Indium In 111 Description
Indium In 111 Chloride Sterile Solution is indicated for radiolabeling ProstaScint™ preparations used for in vivo diagnostic imaging procedures. It is also indicated for radiolabeling Zevalin™ preparations used for Radioimmunotherapy procedures. It is supplied as a sterile, non-pyrogenic solution of Indium In 111 Chloride in 0.05 molar hydrochloric acid. No carrier has been added to the solution. Each 0.5 milliliter of the solution contains 185 megabequerels (5 millicuries) of Indium In 111 Chloride at time of calibration (specific activity of >1.85 GBq/μg Indium; >50 mCi/μg Indium at this time of calibration). The solution pH is 1.1 to 1.4.
Radionuclidic Purity
Indium In-111 is cyclotron produced by the proton irradiation ((p,2n) reaction) of cadmium Cd-112 enriched target. At time of calibration, it contains not less than 99.925% indium In-111 and, not more than 0.075% indium In-114m and zinc Zn-65 combined. At the time of expiration, it contains not less than 99.85% indium 111 and not more than 0.15% indium In-114m and zinc Zn-65 combined. No carrier has been added.
Radiochemical Purity
At the time of calibration, the Indium In 111 Chloride Sterile Solution contains not less than 95% of the Indium present as ionic In3+.
Chemical Purity
Indium In 111 Chloride Sterile Solution is tested for the following metallic impurities: copper, iron, cadmium, lead, zinc, nickel, and mercury, and contains extremely low levels of these metals. The sum of the individual impurity ratios for the metals listed is not more than 0.60 ppm.
Physical Characteristics
Indium In-111 decays by electron capture to cadmium Cd-111 (stable) with a physical half-life of 67.32 hours (2.81 days) (see Table 2)1. Photons useful for detection and imaging are listed in Table 1.
