Indocyanine Green

Dosage form: injection
Drug classes:Miscellaneous diagnostic dyes, Ophthalmic diagnostic agents

Medically reviewed by Drugs.com. Last updated on Jun 1, 2021.

Indications and Usage for Indocyanine Green

Indocyanine Green for injection is indicated:

For Determining Cardiac Output, Hepatic Function and Liver Blood Flow

For ophthalmic angiography

Indocyanine Green Dosage and Administration

Indicator-Dilution Studies

In the performance of dye dilution curves, a known amount of dye is injected as a single bolus as rapidly as possible via a cardiac catheter into selected sites in the vascular system. A recording instrument (oximeter or densitometer) is attached to a needle or catheter for sampling of the dye‑blood mixture from a systemic arterial sampling site.

Under sterile conditions, the Indocyanine Green for injection powder should be dissolved with the Sterile Water for injection provided for this product, and the solution used within 6 hours after it is prepared. If a precipitate is present, discard the solution.

The usual doses of Indocyanine Green for injection for dilution curves are as follows:

Adults - 5.0 mg
Children - 2.5 mg
Infants - 1.25 mg

These doses of the dye are usually injected in 1 mL volume. An average of five dilution curves are recommended in the performance of a diagnostic cardiac catheterization. The total dose of dye injected should be kept below 2 mg/kg.

While sterile water for injection may be used to rinse the syringe, isotonic saline should be used to flush the residual dye from the cardiac catheter into the circulation so as to avoid hemolysis. With the exception of the rinsing of the dye injection syringe, saline should be used in all other parts of the catheterization procedure.

Calibrating Dye Curves: To quantitate the dilution curves, standard dilutions of Indocyanine Green for injection in whole blood are made as follows. It is strongly recommended that the same dye that was use.