Medically reviewed by Drugs.com. Last updated on Jun 4, 2022.
Increased risk of serious infections leading to hospitalization or death, including TB, bacterial sepsis, invasive fungal infections (such as histoplasmosis) and infections due to other opportunistic pathogens. Discontinue infliximab-axxq if a patient develops a serious infection. Perform test for latent TB; if positive, start treatment for TB prior to starting infliximab-axxq. Monitor all patients for active TB during treatment, even if initial latent TB test is negative. Lymphoma and other malignancies, some fatal, have been reported in children and adolescent patients treated with tumor necrosis factor (TNF) blockers, including infliximab. Postmarketing cases of fatal hepatosplenic T-cell lymphoma (HSTCL) have been reported in patients treated with TNF blockers including infliximab products. Almost all had received azathioprine or 6-mercaptopurine concomitantly with a TNF-blocker at or prior to diagnosis. The majority of reported cases have occurred in patients with Crohn’s disease or ulcerative colitis, most of whom were adolescent or young adult males .
Commonly used brand name(s)
In the U.S.
- AVSOLA
Available Dosage Forms:
- Powder for Solution
Therapeutic Class: Immunological Agent
Pharmacologic Class: Infliximab
Uses for infliximab-axxq
Infliximab-axxq injection is used to reduce the symptoms of moderate-to-severely active Crohn's disease and ulcerative colitis in adults and children who have been previously treated with other medicines but did not work well.
Infliximab-axxq injection is used alone or together with other medicines (eg, methotrexate) to reduce the symptoms and prevent the progression of moderate-to-severely active rheumatoid arthritis, psoriatic arthritis, and active ankylosing spondylitis.
Infliximab-axxq injection is also used to treat chronic severe (extensive or disabling) plaque psoriasis, which is a skin disease with red patches and white scales that do not go away. It is used in patients who cannot be treated with other medicines.
Infliximab-axxq is a monoclonal antibody that works to enhance and improve the immune system.
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