Iron Preparations, Oral

Class: Iron Preparations
CAS Number: 1332-96-3
Brands: Feosol, Feostat, Feratab, Fer-Gen-Sol, Fergon, Fer-In-Sol, Ferrex, Ferrous Sulfate Tablets EC, Fe-Tinic, Hemocyte, Hytinic, Icar Pediatric, Ircon, Mol-Iron, Nephro-Fer, Niferex, Slow FE

Introduction

Ferrous fumarate, ferrous gluconate, ferrous sulfate, carbonyl iron, and polysaccharide-iron complex are used orally in the prevention and treatment of iron deficiency.

Uses for Iron Preparations, Oral

Prevention and Treatment of Iron Deficiency

Prevention and treatment of iron deficiency. Not indicated for treatment of anemia resulting from causes other than iron deficiency.

Iron Preparations, Oral Dosage and Administration

Administration

Oral Administration

Administer orally between meals (e.g., 1 hour before or 2 hours after a meal).

For patients who have difficulty tolerating oral iron supplements, administer smaller, more frequent doses; start with a lower dose and increase slowly to the target dose; try a different form or preparation; or take with or after meals or at bedtime.

Dosage

Dosage expressed in terms of elemental iron. (See Table 1.)

Do not exceed recommended dosage.

Carbonyl iron is elemental iron, not an iron salt.

Table 1. Approximate Elemental Iron Content of Various Oral Iron Preparationsa
Drug	Elemental Iron
Ferric pyrophosphate	120 mg/g
Ferrous gluconate	120 mg/g
Ferrous sulfate	200 mg/g
Ferrous sulfate, dried	300 mg/g
Ferrous fumarate	330 mg/g
Ferrous carbonate, anhydrous	480 mg/g
Carbonyl iron	1000 mg/g

Pediatric Patients

Iron Deficiency Anemia

Prevention

Oral

Premature or low-birthweight infants: 2–4 mg/kg daily starting preferably at 1 month, but at least by 2 months, of age. Do not exceed 15 mg daily.

Normal full-term infants who are not breast-fed or are only partially breast-fed: 1 mg/kg daily, preferably as iron-fortified formula, starting at birth and continuing during the first year of life. Do not exceed 15 mg daily.

Children ≥10 years of age who have begun their pubertal growth spurt may require daily iron supplementation of 2 or 5 mg daily in males or females, respectively.

Based on the need to maintain a normal functional iron concentration but only minimal stores, RDA is the goal for dietary intake in individuals.

Established for infants through 6 months of age based on the observed mean iron intake of infants fed principally human milk.

Table 2. Recommended Dietary Allowance (RDA)/Adequate Intake (AI) of Iron for Pediatric Patients188
Age	RDA (mg/day)	AI (mg/day)
Infants 0–6 months of age		0.27
Infants 7–12 months of age	11
Children 1–3 years of age	7
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