Iron Sucrose
Class: Iron Preparations
Chemical Name: iron saccharate
CAS Number: 8047-67-4
Brands: Venofer
Introduction
Hematinic agent; a polynuclear iron (III)-hydroxide sucrose complex.
Uses for Iron Sucrose
Iron Deficiency Anemia in Patients with Chronic Kidney Disease
Treatment of iron deficiency anemia in patients with chronic kidney disease (CKD), including those who are undergoing dialysis (hemodialysis or peritoneal) and those who do not require dialysis.
In patients with CKD on hemodialysis, IV iron superior to orally administered iron in increasing hemoglobin concentrations and/or minimizing dosage of an erythropoiesis-stimulating agent (ESA); the National Kidney Foundation Kidney Disease Outcomes Quality Initiative (NKF-KDOQI) guidelines state that the IV route of iron administration is preferred in such patients.
Available data suggest that iron sucrose and sodium ferric gluconate may be associated less frequently with serious adverse effects (e.g., hypersensitivity reactions) than iron dextran.
Iron sucrose injection also used as iron maintenance therapy in children with dialysis-dependent (hemodialysis or peritoneal dialysis) or non-dialysis-dependent CKD. (See Pediatric Use under Cautions.)
Iron Sucrose Dosage and Administration
General
Although manufacturer makes no specific recommendations regarding test doses, test doses of iron sucrose (20–25 or 50 mg) have been administered in some patients. (See Sensitivity Reactions under Cautions.)
Ensure immediate availability of personnel trained to provide emergency treatment and appropriate agents for the treatment of a severe allergic or anaphylactic reaction when administering iron sucrose injection.
Administration
IV Administration
For solution and drug compatibility information, see Compatibility under Stability.
Administer (diluted) by IV infusion or (undiluted) by slow IV injection.
Do not mix with other drugs or add to parenteral nutrition solutions for IV infusion.
Dilution
For IV infusion, dilute in 0.9% sodium chloride injection; specific recommendations for dilution vary depending on the intended patient population (see Dosage). Do not dilute to concentrations <1 mg/mL.
Dosage
Dosage expressed in terms of mg of elemental iron. Iron sucrose injection contains the equivalent of 20 mg of elemental iron per mL.
Pediatric Patients
Iron Maintenance Treatment in Patients with Hemodialysis-dependent CKD
IV
Children ≥2 years of age: 0.5 mg/kg (not to exceed 100 mg per dose) every 2 weeks for 12 weeks; may administer undiluted by slow IV injection over 5 minutes or diluted in 25 mL of 0.9% sodium chloride injection over 5–60 minutes.
Repeat treatment if necessary.
Iron Maintenance Treatment in Patients with Non-dialysis-dependent CKD Receiving ESAs
IV
Children ≥2 years of age: 0.5 mg/kg (not to exceed 100 mg per dose) every 4 weeks for 12 weeks; may administer undiluted by slow IV injection over 5 minutes or diluted in...
