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Isoflurane Veterinary
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  • FDA PI

Isoflurane Veterinary

Generic name: isoflurane inhalant
Dosage form: FOR ANIMAL USE ONLY

WARNING: Not for use in horses intended for food
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.

Isoflurane Veterinary Description

Isoflurane (Isoflurane, USP) is a nonflammable, nonexplosive general inhalation anesthetic agent. Its chemical name is 1-chloro-2,2,2-trifluoroethyl difluoromethyl ether, and its structural formula is:


Each mL contains 99.9% Isoflurane.

Some physical constants are:

Molecular weight

184.5
Boiling point at 760 mmHg

48.5°C (uncorr.)
Refractive i n d e x n20/D
1.2990-1.3005
Specific gravity 25°/25°C

1.496
Vapor pressure in mmHg**
20°C 238


25°C 295


30°C 367


35°C 450
**Equation for vapor pressure calculation:
log10Pvap = A + B/T

where: A = 8.056
B = -1664.58
T = °C + 273.16 (Kelvin)

Partition coefficients at 37°C

Water/gas
0.61
Blood/gas
1.43
Oil/gas
90.8
Partition coefficients at 25°C - rubber and plastic

Conductive rubber/gas
62.0
Butyl rubber/gas
75.0
Polyvinyl chloride/gas
110.0
Polyethylene/gas
~2.0
Polyurethane/gas
~1.4
Polyolefin/gas
~1.1
Butyl acetate/gas