Ivacaftor and lumacaftor
Generic name: ivacaftor and lumacaftor [ EYE-va-KAF-tor-and-LOO-ma-KAF-tor ]
Brand name: Orkambi
Dosage forms: oral granule for reconstitution (125 mg-100 mg; 188 mg-150 mg); oral tablet (125 mg-100 mg; 125 mg-200 mg)
Drug class:CFTR combinations
What is ivacaftor and lumacaftor?
Ivacaftor and lumacaftor is a combination medicine used to treat cystic fibrosis in adults and children who are at least 2 years old.
Ivacaftor and lumacaftor is for use only in patients with a specific gene mutation related to cystic fibrosis. Before you take ivacaftor and lumacaftor, you may need a medical test to make sure you have this gene mutation.
Ivacaftor and lumacaftor may also be used for purposes not listed in this medication guide.
Warnings
Tell your doctor about all your current medicines and any you start or stop using. Many drugs can interact, and some drugs should not be used together.
Before taking this medicine
You should not use ivacaftor and lumacaftor if you are allergic to ivacaftor or lumacaftor.
Some medicines can cause unwanted or dangerous effects when used with ivacaftor and lumacaftor. Your doctor may change your treatment plan if you also use:
medicine to prevent organ transplant rejection--cyclosporine, everolimus (Zortress), sirolimus, tacrolimus;
seizure medicine--carbamazepine, phenobarbital, phenytoin; or
tuberculosis medicine--rifabutin, rifampin.
Tell your doctor if you have ever had:
kidney disease;
asthma or other lung disease; or
an organ transplant.
Tell your doctor if you are pregnant or breastfeeding.
Ivacaftor and lumacaftor can make hormonal birth control less effective, including
