Kalosar

Generic name:calcipotriene
Dosage form: ointment
Drug class:Topical antipsoriatics

Medically reviewed by Drugs.com. Last updated on Apr 21, 2022.

Rx Only

FOR TOPICAL DERMATOLOGIC USE ONLY.

Not for Ophthalmic, Oral or Intravaginal Use.

Kalosar Description

Kalosar™ (calcipotriene) Ointment USP, 0.005% contains the compound calcipotriene, USP, a synthetic vitamin D3 derivative for topical dermatological use.

Chemically, calcipotriene, USP is 24-cyclopropyl-(1α,3β,5Z,7E,22E,24S)-9,10-Secochola-5,7,10(19),22-tetraene-1,3,24-trioI; with the empirical formula C27H40O3, a molecular weight of 412.62, and the following structural formula:

Calcipotriene, USP is a white or almost white, crystalline powder. Kalosar (calcipotriene) Ointment USP, 0.005% contains calcipotriene, USP 50 mcg/g in an ointment base of disodium phosphate dihydrate, edetate disodium, mineral oil, white petrolatum, propylene glycol, dl-alpha-tocopherol, steareth-2 and purified water.

Kalosar - Clinical Pharmacology

Clinical studies with radiolabelled calcipotriene ointment indicate that approximately 6% (± 3%, SD) of the applied dose of calcipotriene is absorbed systemically when the ointment is applied topically to psoriasis plaques or 5% (± 2.6%, SD) when applied to normal skin, and much of the absorbed active is converted to inactive metabolites within 24 hours of application.

Vitamin D and its metabolites are transported in the blood, bound to specific plasma proteins. The active form of the vitamin, 1, 25-dihydroxy vitamin D3 (calcitriol), is known to be recycled via the liver and excreted in the bile. Calcipotriene metabolism following systemic uptake is rapid, and occurs via a similar pathway to the natural hormone. The primary metabolites are much less potent than the parent compound.

There is evidence that mate...